Figure 2.

Globally perturbing the inhibitory network gives rise to a paradoxical inhibitory response in ISNs. A, B, Effect on activity of excitatory and inhibitory neurons in an ISN model of 100 fully connected firing rate neurons of increasing (A) and decreasing (B) excitatory input to the inhibitory population (see Materials and Methods). At 50 ms input is injected to all neurons. At 100 ms, only the input to the inhibitory population is perturbed. Note that increasing the inhibitory input results in a counterintuitive decrease in overall inhibitory activity and vice versa. Parameters: {w_E, w_I, τ} = {5, 20, 10 ms}. Dashed line is shown for reference to preperturbation activity.