Table 4.

Survival Analysis—Cox Proportional Hazards Model, Showing Adjusted Hazard Ratios of Death (n = 322 Patients).

	Hazard ratio (95% CI)	P-value
Cr Peak 48 h
<1.2 mg/dL, increment +0 to 0.29	Ref.
<1.2 mg/dL, increment +0.3+	0.79 (0.24–2.60)	0.70
1.2+ mg/dL, increment +0 to 0.29	1.37 (0.91–2.08)	0.13
1.2+ mg/dL, increment +0.3+	2.51 (1.65–3.81)	<0.01a
INR (per +0.1 above 1)	1.03 (1.00–1.05)	0.04
TBILI (per +1 mg/dL above 1)	1.02 (0.99–1.05)	0.14
Na (per −1 mEq/L below 135)	1.05 (1.01–1.09)	0.02
MAP
Normal (70+ mmHg)	Ref.
Abnormal (<70 mmHg)	1.37 (0.89–2.11)	0.16
Reason for admission
6-Ref. Asc.	Ref.
1-Enceph.	1.98 (1.20–3.27)	0.01
7-SBP	2.61 (1.36–5.03)	<0.01
8-Sepsis	1.45 (0.82–2.58)	0.20
9-GI bleed	0.90 (0.50–1.62)	0.73
Age (per +1 year)	1.02 (1.00–1.04)	0.02
Race
Black or other	Ref.
White	1.31 (0.93–1.85)	0.13
Sex
Female	Ref.
Male	1.29 (0.93–1.82)	0.13

^aHazard ratio 1.83 (95% CI 1.24–2.70) (P < 0.01) compared to “1.2+ mg/dL, increment +0 to 0.29″. Also, Hazard ratio 3.16 (95% CI 0.96–10.48) (P = 0.06) compared to “<1.2 mg/dL, increment +0.3+”.

Interpretations:

Those with a high peak (1.2+) and high increment (+0.3+) had significantly worse survival (151% worse) than those with a low peak (<1.2) and low increment (<+0.3).

Those with a high peak and high increment also had significantly worse survival (83% worse) than those with a high peak (1.2+) and low increment (<+0.3).

These hazard ratios take into account all other variables in the table.

INR: international normalized ratio; TBILI: total bilirubin; Na: sodium; MAP: mean arterial pressure.

Single Cox regression model, adjusted for all variables in the table.

Data from 607 admissions were used. Deaths were recorded for 158 patients in this sample.