Table 7.

Factors associated with roflumilast adverse events (multivariate analysis)

Risk factor	OR	95% CI	p-value
Model A
Age	1.001	0.960–1.043	0.969
BMI (per 1-unit decrease)	1.151	1.034–1.281	0.010
Sex (female)	0.699	0.198–2.459	0.576
% of predicted post-bronchodilator FEV1	1.015	0.990–1.041	0.230
Model B
Age	1.000	0.960–1.042	0.987
BMI <23 kg/m2	2.644	1.270–5.505	0.009
Sex (female)	0.610	0.174–2.142	0.440
% of predicted post-bronchodilator FEV1	1.019	0.994–1.044	0.141

Notes: Model A is the result of analyzing BMI as a continuous variable. Model B is the result of analyzing BMI as a nominal variable.

Abbreviations: BMI, body mass index; FEV₁, forced expiratory volume in 1 second; OR, odds ratio.