Skip to main content
. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Cancer Lett. 2017 Sep 28;411:136–149. doi: 10.1016/j.canlet.2017.09.033

Table 2.

IC50 values for GLI antagonists tested in 3D tumor spheroid assay.

IC50 (µM)a
SUM149 MDA-MB-231 SUM159
Stauropsorine Spheroid Area 0.011 No curve 0.007
Spheroid YOYO-1 0.021 No curve 0.065
GANT61 Spheroid Area 18 16.7 22.6
Spheroid YOYO-1 25.9 No curve 37.8
a

GLI antagonists were tested in dose response in 3D tumor spheroid assay, stained with Hoechst and YOYO-1 and imaged as described in Materials and Methods. IC50 values were determined by non-linear regression in Graphpad Prism 6. A minimum of three independent experiments were conducted.