. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Cell Microbiol. 2017 Oct 4;19(12):10.1111/cmi.12767. doi: 10.1111/cmi.12767

Table 1.

Functional categories of C. albicans genes whose transcript levels in the rta3Δ/Δ strain are 1.5-fold up- and down- regulated (P≤ 0.05)

Category and System Name	Gene	Function	Fold Change
Adhesion
orf19.1816	ALS3^a,^b	Cell wall adhesin; epithelial adhesion	−7.27
orf19.1756	GPD1^b	Glycerol-3-phosphate dehydrogenase biosynthesis	1.84
orf19.691	GPD2^b	Surface protein similar to glycerol 3-P dehydrogenase	1.68
orf19.5804	HYU1	Putative hydantoin utilization protein A	1.93
Cell Surface
orf19.6420	PGA13^b	GPI-anchored cell wall protein involved in cell wall synthesis	−4.35
orf19.3740	PGA23	Putative GPI-anchored protein of unknown function	−1.69
General stress
orf19.2849	AQY1^b	Aquaporin water channel; osmotic shock resistance	1.68
orf19.359	GTT12	glutathione transferase activity	1.72
orf19.5068	IRE1^b	Putative protein kinase; role in cell wall regulation	2.53
Hyphal formation and Virulence
orf19.3374	ECE1^b,^b	Hypha-specific protein	−22.23
orf19.1321	HWP1^a,^b	Hyphal cell wall protein^a	−19.98
orf19.4975	HYR1^b	GPI-anchored hyphal cell wall protein	−1.64
orf19.5585	SAP5^b	Secreted aspartyl proteinase	−2.16
orf19.2770.1	SOD1^b	GPI-anchored cell wall protein involved in cell wall synthesis	−4.35
orf19.1822	UME6^a,^b	Zn(II)2Cys6 transcription factor	−4.06
Iron Assimilation
orf19.4215	FET34^b	Multicopper ferroxidase	−1.78
orf19.6139	FRE7^b	Copper-regulated cupric reductase	−2.89
orf19.1415	FRE10^b	Major cell-surface ferric reductase under low-iron conditions	−1.80
orf19.7219	FTR1	High-affinity iron permease	−2.17
Membrane Structure
orf19.6169	ATO1^b	Putative fungal-specific transmembrane protein	−8.44
orf19.700	SEO1^b	Protein with similarity to permeases	−2.10
Metabolic Enzymes
orf19.5565	HPD1^b	3-hydroxypropionate dehydrogenase; involved in degradation of toxic propionyl-CoA	−9.45
Mitochondrial Function and Oxidation-Reduction Processes
orf19.5806	ALD5^b	NAD-aldehyde dehydrogenase	−2.00
orf19.742	ALD6^b	Putative aldehyde dehydrogenase	−2.43
orf19.2060	SOD5^a,^b	Cu and Zn-containing superoxide dismutase; protects against oxidative stress	−6.58
Transport
orf19.3646	CTR1^b	Copper transporter	−2.90
orf19.6993	GAP2 ^b	General amino acid permease;	−2.08
orf19.3981	MAL31 ^b	Putative high-affinity maltose transporter	−1.90
orf19.2602	OPT1^b	Oligopeptide transporter	−1.78
orf19.5673	OPT7^b	Putative oligopeptide transporter	−2.21

Genes that were validated by qPCR

Genes that are annotated as flow model/RPMI/Spider/rat catheter biofilm induced or repressed in CGD