Table 2.
Reported case series of adverse pregnancy-associated complications in pregnant women diagnosed with brucellosis
| Study year and country |
Pregnant womena |
Diagnostic criteria | Spontaneous abortion rate |
Preterm delivery rate |
Intrauterine fetal death rate |
Associated clinical signs |
Reference |
|---|---|---|---|---|---|---|---|
| 2015, Peru | 86 | SAT (>1/160) and blood culture | 16 (18.6 %) | 12 (13.9 %) | 7 (8.14 %) | Osteoarticular, haematological and congenital disorders | [22] |
| 2014, Africa | 15 | RBPT | 11 (73.3 %) | – | 4 (26.7 %) | – | [41] |
| 2011, Turkey | 39 | Coombs test (>1/160) and blood culture | 1 (2.56 %) | 7 (17.95 %) | – | Fever, arthralgia, myalgia, hepatospenomegaly | [32] |
| 2011, Iran | 19 | SAT (>1/160), 2ME titer >1/80 | 10 (53 %) | – | – | Fever, arthralgia, back pain, sweating | [31] |
| 2010, Turkey | 29 | SAT (>1/160) and blood culture | 7 (24.14 %) | 2 (6.9 %) | 1 (3.45 %) | Sacroiliitis with Joint pain, hepatosplenomegaly | [27] |
| 2008, Saudi Arabia and Kuwait | 55 | SAT (>1/160) | 19 (34.5 %) | 13 (23.6 %) | 11 (20 %) | Common symptoms and signs of brucellosis in 35 women | [25] |
| 2001, Saudi Arabia | 92 | SAT (1:2560) and blood culture | 40 (43.5 %) | – | 2 (2.17 %) | Vaginal bleeding, febrile illness, 24 patients with recurrent abortion | [21•] |
| 2001, Saudi Arabia | 30 | SAT and blood culture | 12 (41 %) | 9 (30 %) | 1 (3.4 %) | Fever, arthritis, headache, sweating, | [42] |
| 1998, Kuwait | 25 | SAT (1/160), ELISA and tissue culture | 2 (8 %) | 18 (72 %) | 5 (20 %) | Fever, arthralgia, myalgia backache, headache, anorexia | [43] |
| 1991, Lebanon | 6 | SAT (>1/160, direct >1/80) | 1 (17 %) | 1 (17 %) | – | Fever, back pain, sweating, fatigue and malaise, chills | [36] |
| 1988, Kuwait | 35 | SAT (>1/160) and ELISA: (IgG>1/1600, IgM>1/400, IgA≫1/200) | 11 (31.4 %) | – | – | Fever, arthralgia, back pain, hepatosplenomegaly, headache, sweating | [44] |
| 1974, Iran | 51 | SAT, urine, uterine and blood culture | 6 (11.6 %) | – | – | Undulant fever, arthralgia, sweating and muscle pain | [45] |
| 1954, Argentina | 200 | SAT | 52 (26 %) | – | – | Febrile and non-febrile | [38] |
a
Positive for Brucella. Fetal death before 24 weeks of gestation is considered spontaneous abortion and fetal death after 24 weeks of gestation is considered intrauterine fetal death. Delivery before 37 weeks is considered preterm delivery. SAT serum agglutination test, RBPT Rose Bengal plate test