Figure 1.
Genome-wide dN/dS Ratios Show a Distinct Pattern of Selection Universally Shared across Cancer Types
(A) Species evolution: median dN/dS ratios across genes for missense mutations (data from Martincorena et al. [2012] and Ensembl). Data on germline human SNPs are from the 1,000 genomes phase 3 (Auton et al., 2015), restricted to SNPs with minor allele frequency ≥5%.
(B) Cancer evolution: genome-wide dN/dS values for missense and nonsense mutations across 23 cancer types.
(C) Somatic mutations in normal tissues (data from Blokzijl et al., 2016, Martincorena et al., 2015, Welch et al., 2012). Error bars depict 95% CIs.