Figure 3.

HLA LOH Reflects Selection in NSCLC

(A and B) Frequency of focal LOH in lung adenocarcinoma (A) and lung squamous cell carcinoma (B). Focal LOH is defined as <75% of a chromosome arm. Arrow indicates location of HLA locus. Horizontal dashed line depicts significant focal LOH at p = 0.05, using simulations. Clonal LOH is shown in blue, with subclonal LOH shown in red. Chromosome arm LOH and focal subclonal LOH is shown in Figure S3.

(C) Parallel evolution of HLA LOH, with allele-specific HLA loss shown on phylogenetic trees.

See also Figure S3.