Figure 3.

Effects of Combination of CUR with Ara-c, IDA, and DNR on Cell Viability. The anti-growth effect of CUR and combination with three drugs were measured by MTT assay following 24-48h in KG-1 and U937 cell lines. Data indicated that the antiproliferative effect of this drugs leads to a reduction of viability and number of cells in a dose and time dependent manner. The combination of CUR and three drugs were highly effective in inhibiting cell growth and promoting massive apoptosis in both cell lines. The combination of CUR and Ara-c is better than two other combinations. Combination effect of CUR and Ara-c compared to the control or even single compound could significantly decrease cell proliferation in both U937 and KG-1 cell lines. Data are mean ± SE of three independent experiments. Statistical significance was defined at *p<0.05, **p<0.01 and ***p<0.001 compared to corresponding control.