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. Author manuscript; available in PMC: 2018 Jun 8.
Published in final edited form as: J Med Chem. 2017 Apr 28;60(11):4680–4692. doi: 10.1021/acs.jmedchem.7b00304

Figure 7.

Figure 7

Compound 4p induced Ca2+ transients in rat glomerular mesangial cells. (A) Representative traces of Fluo4-loaded mesangial cells exposed to 1 μM compound 4p. Each trace represents a single cell, and the thick gray line is the average of all 36 cells in the same coverslip. (B) Similar to (A), but the cells were pretreated for 2 min with 30 μM 2-APB, which was also present throughout the period when compound 4p was applied. Each trace represents a single cell, and the thick gray line is the average of all 30 cells in the same coverslip. (C) Summary of four experiments quantified by the mean peak fluorescence changes induced by compound 4p for the individual experiments. * p < 0.05 compared to no 2-APB control by Student’s t test.