Table 3. Hazard ratio for CKD occurring during the initial regimen type.

	Hazard ratio (95%CI)	p
Crude model (unadjusted)	87 events
TDF+/rbPI vs. TDF+/NNRTI	3.14 (1.4–7.0)	0.005
TDF-/NNRTI vs. TDF+/NNRTI	1.22 (0.3–4.8)	0.77
TDF-/rbPI vs. TDF+/NNRTI	2.38 (1.0–5.5)	0.04
Adjusted model *
TDF+/rbPI vs. TDF+/NNRTI	3.07 (1.3–7.1)	0.009
TDF-/NNRTI vs. TDF+/NNRTI	1.26 (0.3–5.2)	0.74
TDF-/rbPI vs. TDF+/NNRTI	2.06 (0.8–5.0)	0.11
Causal approach
Weighted model
TDF+/rbPI vs. TDF+/NNRTI	2.71 (1.3–5.6)	0.007
TDF-/NNRTI vs. TDF+/NNRTI	1.18 (0.3–4.4)	0.81
TDF-/rbPI vs. TDF+/NNRTI	2.13 (1.0–4.6)	0.05
Double robust estimators
TDF+/rbPI vs. TDF+/NNRTI	3.25 (1.5–6.9)	0.002
TDF-/NNRTI vs. TDF+/NNRTI	1.18 (0.3–4.5)	0.81
TDF-/rbPI vs. TDF+/NNRTI	2.08 (0.9–4.6)	0.07

*All model were adjusted for age at initiation, CD4 cell count nadir, baseline CD4 cell count, baseline viral load (HIV-1 RNA), baseline eGFR, year of ART initiation, gender, HIV exposure (homosexual vs. heterosexual vs. other), HCV or HBV co-infections, prior diabetes, prior hypertension, prior cardiovascular disease, time-varying CD4 cell count and time-varying viral load