Fig 4. Kctd15 is required for proper jaw formation later in development.

Alcian blue/Alizarin red staining does not reveal any early structural abnormalities in the patterning of kctd15 mutant jaws (A,B). However, adult mutants exhibit shortening of several jaw elements, including the dentary, maxillary and frontal regions (C). While mRNA staining at 6 dpf for col10a1a showed no difference in patterning of early craniofacial bones (D,E), adult double mutants lack a properly formed maxilla bone (F,G; abnormalities are indicated by an asterisk and arrow).