Fig 4. Spatial plots showing viral particles levels over cells within a single sinusoid per row (‘unit model’ #1) in three different parameter sets.

Plots are averages of n = 5 simulations that are evolution of only one sinusoid for 3 cases of agent-based stochastic model: (a) Homogeneous baseline case, (b) linear gradient-based heterogeneities of Γ and κ combined, and (c) linear gradient-based heterogeneity of κ alone. Columns correspond to the suite of either sinus particles (V_s, P_Ψ, two leftmost columns) or the full cohort of intracellular particles (V_Φk to R_Φk, 3^rd column to last). For each plot, x-axis represents the time in days, y-axis represents spatial location so that y = 1 is the first hepatocyte cell at the periportal entry of the sinusoid and y = 30 is the 30^th hepatocyte cell at the pericentral end of the sinusoid. Colour bars above each plot show levels of each particle for each respective column across the rows. Inoculation at day t = 0 and activation of immune responses (CYL and non-CYL) at day t = 40 (δ = 0.9, u = 0.25) similar to prior results shown, and cccDNA survival probability to daughter hepatocytes set to zero again. Variance for gradient heterogeneities: 0.8. (See Fig 3 for depiction of these gradient-based distributions.)