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. 2017 Dec 7;12(12):e0188209. doi: 10.1371/journal.pone.0188209

Fig 6. Reinfection of transected or transplanted liver with solo cccDNA copy.

Fig 6

Results here with increased hepatocyte population than in other results: 50 sinusoids of 300 hepatocytes or 15,000 total cells, all homogeneously distributed (no spatial gradients of any parameters). This corresponds to 0.006% of cell population with 1 cccDNA. cccDNA survival probability to replenishment hepatocytes here set to zero. (1) Evolution of HBV from only 0.006% cells infected with 1 cccDNA without any immune response (2)(1) Evolution of HBV from only 0.006% cells infected with 1 cccDNA with activation of a weak immune response at day 10 (δ = 0.3, u = 0.25) Legend: Plain lines represent percentage of cells in the liver with at least 1 HBV copy (VΦk+RΦk). Dotted lines represent percentage of cells in the liver with at least 1 cccDNA copy.