. 2017 Dec 7;12(12):e0188944. doi: 10.1371/journal.pone.0188944

Table 3. Mutations in MHR (aa 99–169) including “a” determinant region (aa 124–147).

Amino acid position	All	Genotype A	Genotype C	Genotype D	Reference
	% (no)	% (no)	% (no)	% (no)
	N = 53	n = 10	n = 24	n = 19
Y100C^IV	3.8 (2)	0 (0)	8.3 (2)	0 (0)	[22]
Q101K	3.8 (2)	0 (0)	8.3 (2)	0 (0)	[22]
Q101R ^IV	1.9 (1)	0 (0)	4.2 (1)	0 (0)	[22]
L100I ^IV	1.9 (1)	0 (0)	4.2 (1)	0 (0)	[22]
T113S ^IV	1.9 (1)	0 (0)	4.2 (1)	0 (0)	[22]
T115N ^II^,^IV	1.9 (1)	0 (0)	0 (0)	5.3 (1)	[22]
I/T126N ^I^, ^II^,^III^,^IV	3.8 (2)	0 (0)	4.2 (1)	5.3 (1)	[22][23]
I/T126S ^I^, ^II^, ^IV	1.9 (1)	0 (0)	4.2 (1)	0 (0)	[22][23]
T127P	5.7 (3)	0 (0)	0 (0)	15.8 (3)	[22]
A128V	7.6 (4)	0 (0)	0 (0)	21.0 (4)	[22]
S143L ^I^, ^II^, ^IV	1.9 (1)	0 (0)	0 (0)	5.3 (1)	[22][24][26]
G145R ^I^, ^II^, ^III^, ^IV	3.8 (2)	0 (0)	8.3 (2)	0 (0)	[22][24][26]
R160N	1.9 (1)	0 (0)	4.2 (1)	0 (0)	[22]
Y161F	1.9 (1)	10 (1)	0 (0)	0 (0)	[26]
E164D	1.9 (1)	0 (0)	4.2 (1)	0 (0)	[26]
A168V^IV	1.9 (1)	0 (0)	0 (0)	5.3 (1)	[27]

I; Mutations associated with HBsAg detection failure

II; mutations associated with escape mutant

III; mutations associated with therapy escape

IV; mutations associated OBI. Mutation in “a” determinant region is marked in bold. Amino acid positions are relative to HBV reference sequence

GenBank accession number AB014381