. 2017 Dec 7;12(12):e0188944. doi: 10.1371/journal.pone.0188944

Table 5. Genotype–dependent AA polymorphic sites in RT domain of HBV polymerase gene identified in this study.

		rt38			rt53						rt54			rt91		rt124			rt126			rt139				rt153			rt221		rt224		rt256
		A^b	E^a	T	D	I	K^a	N^a	S	V^a	H	T	Y^a	I	L^c	H^b	N	Y	H	R	Y^a	D^a	H^a	N	Q	Q^a	R	W	F	Y^c	I	V^b	C	S
Genotype A	N = 10	10	0	0	0	5	0	0	1	4	0	10	0	10	0	1	9	0	7	0	3	0	0	0	10	0	0	10	0	10	0	10	0	10
Genotype C	N = 24	1	0	23	0	0	0	0	24	0	0	24	0	2	22	2	0	22	24	0	0	1	0	23	0	2	21	1	24	0	22	2	0	24
Genotype D	N = 19	16	1	2	14	0	1	3	1	0	14	2	3	1	18	18	1	0	4	15	0	0	1	18	0	0	19	0	17	2	0	19	17	2
	P value	p < 0.0001			p < 0.0001						p < 0.0001			p < 0.0001		p < 0.0001			p < 0.0001			p < 0.0001				p < 0.0001			p < 0.0001				p < 0.0001

A: alanine; E: glutamic acid; T: threonine; D: aspartic acid; I: isoleucine; K: Lysine; N: asparagine; S: serine, H: histidine; Y: tyrosine; R: Arginine; Q: Glutamine; W: Tryptophan; F: Phenylalanine; G: glycine; F: phenylalanine; V: valine; C: cystine.

^a Described as naturally occurring polymorphic mutations in this study

^b Pretreatment mutation found to be Genotype–dependent AA

^c Putative NAr mutation found to be Genotype–dependent AA