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. 2017 Nov 27;13(11):e1006704. doi: 10.1371/journal.ppat.1006704

Fig 2. Primary and secondary Ag85b-specific CD4+ T cell responses use similar TCRs.

Fig 2

(a) ESAT6- and Ag85b-specific CD4+ T cell responses in infected mice at 2, 4, and 12 wpi. (b) TCR clonality of splenic T cells from normal C57BL/6 mice (n = 3), TB10.4-specific CD8+ T cells (n = 6) (both from [25]), ESAT6-specfic (n = 10) and Ag85b-specific (n = 8) CD4+ T cells from lungs 4–10 wpi; from blood 1 week after Ag85b240-254 vaccination and in the same mice 3 wpi (n = 4). (c) The top clonotypes from the Ag85b- or ESAT6-specific response from each Mtb-infected mouse. (d) CDR3β motifs for primary Ag85b-specific responses derived from TCRβs using TRBV16 with a CDR3β length of 12. (e) CDR3β motifs for Ag85b-specific CD4+ T cells that use TRBV16 with a CDR3β length of 12 in blood 10 d after vaccination (top row), or in lung 3 wpi (bottom row).