Table 2.

Unadjusted and Adjusted Hazard Ratios for Death Associated with Different Types of Events (n=113)^{^}

Event Type	Unadjusted HR	95% CI	Adjusted HR*	95% CI
AIDS event (n=54)	7.8	(3.8 – 16.1)	4.6	(1.8 – 12.0)
CVD event (n=132)	17.1	(11.1 – 26.1)	17.1	(10.0 – 29.3)
Non-AIDS cancer event (n=86)	34.6	(22.6 – 53.1)	26.8	(15.7 – 45.7)
Any grade 4 event (n=339)	8.9	(6.0 – 13.2)	6.9	(4.2 – 11.2)
-ChrIRD grade 4 event# (n=165)	13.0	(8.5 – 19.9)	12.4	(7.4 – 20.8)
-Non-ChrIRD grade 4 event# (n=214)	6.6	(4.3 – 10.3)	5.2	(3.0 – 8.9)

^*Adjusted HRs for risk of death for those who did vs. those who did not experience an event use a time-dependent indicator for event type. Other covariates in the model include: age, race, gender, baseline log₂ IL-6, baseline log₂ D-dimer, baseline BMI, baseline log₁₀ CD4, log₁₀ nadir CD4, prior AIDS event, Hepatitis B or C co-infection, use of lipid-lowering medication, use of blood pressure medication, and type of ART treatment.

^{^}All models were stratified by study (ESPRIT or SMART).

^#Some subjects have both a ChrIRD event and a non-ChrIRD event. These subjects would only be counted once for grade 4 events.

CVD = cardiovascular disease

ChrIRD = chronic inflammation-related disease