Table 3.
Baseline IL-6 and D-dimer Levels of SMART and ESPRIT Participants with and without an Event
| SMART and ESPRIT Events | |||||
|---|---|---|---|---|---|
|
| |||||
| No Event | Event | Unadjusted HR* | 95% CI* | P-value* | |
| AIDS events (n) | 3514 | 54 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.72 (1.10 – 2.71) | 2.05 (1.40 – 3.30) | 1.36 | (1.05 – 1.77) | 0.019 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.15 – 0.35) | 0.26 (0.18 – 0.38) | 1.29 | (1.01 – 1.64) | 0.040 |
|
| |||||
| CVD events (n) | 3436 | 132 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.70 (1.10 – 2.70) | 2.50 (1.70 – 3.83) | 1.51 | (1.29 – 1.76) | <0.001 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.15 – 0.34) | 0.29 (0.20 – 0.47) | 1.36 | (1.17 – 1.57) | <0.001 |
|
| |||||
| Non-AIDS cancer events (n) | 3488 | 80 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.70 (1.10 – 2.70) | 2.20 (1.70 – 3.32) | 1.39 | (1.13 – 1.70) | 0.002 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.15 – 0.34) | 0.27 (0.17 – 0.47) | 1.27 | (1.05 – 1.54) | 0.014 |
|
| |||||
| Grade 4 events (n) | 3229 | 339 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.70 (1.10 – 2.70) | 2.19 (1.50 – 3.60) | 1.36 | (1.23 – 1.51) | <0.001 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.14 – 0.34) | 0.28 (0.19 – 0.46) | 1.31 | (1.19 – 1.44) | <0.001 |
| ChrIRD grade 4 events# (n) | 3403 | 165 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.70 (1.10 – 2.70) | 2.40 (1.67 – 4.15) | 1.58 | (1.37 – 1.81) | <0.001 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.15 – 0.34) | 0.29 (0.19 – 0.46) | 1.35 | (1.17 – 1.55) | <0.001 |
| Non-ChrIRD grade 4 events# (n) | 3354 | 214 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.70 (1.10 – 2.70) | 2.10 (1.40 – 3.50) | 1.24 | (1.09 – 1.42) | 0.002 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.14 – 0.34) | 0.28 (0.19 – 0.47) | 1.29 | (1.14 – 1.46) | <0.001 |
|
| |||||
| Deaths (n) | 3455 | 113 | |||
| IL-6 [median (IQR)] (pg/ml) | 1.70 (1.10 – 2.70) | 2.94 (1.90 – 4.20) | 1.83 | (1.55 – 2.15) | <0.001 |
| D-dimer [median (IQR)] (μg/ml) | 0.22 (0.15 – 0.34) | 0.33 (0.22 – 0.55) | 1.52 | (1.29 – 1.79) | <0.001 |
*
From an unadjusted Cox regression model on the log2 transformed baseline IL-6 and D-dimer variables.
^
All models were stratified by study (ESPRIT or SMART).
#
Some subjects have both a ChrIRD event and a non-ChrIRD event. These subjects would only be counted once for grade 4 events, so the ChrIRD and non-ChrIRD event counts do not sum to the grade 4 event count.
CVD = cardiovascular disease
ChrIRD = chronic inflammation-related disease