. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: J Acquir Immune Defic Syndr. 2018 Jan 1;77(1):1–7. doi: 10.1097/QAI.0000000000001554

Table 4.

Adjusted Hazard Ratios for Time to First Event^{^}

	IL-6 (log₂ pg/ml)^*			D-dimer (log₂ μg/ml)^*

Event	HR	95% CI	P-value	HR	95% CI	P-value
AIDS	1.36	(1.00 – 1.85)	0.048	1.23	(0.92 – 1.64)	0.17
CVD	1.29	(1.06 – 1.56)	0.010	1.19	(1.00 – 1.41)	0.054
-CVD by ERC	1.37	(1.09 – 1.72)	0.008	1.16	(0.94 – 1.43)	0.16
-CVD by grade 4⁺	1.15	(0.81 – 1.63)	0.44	1.24	(0.92 – 1.67)	0.17
Non-AIDS Cancer	1.22	(0.94 – 1.57)	0.13	1.04	(0.83 – 1.31)	0.75
Grade 4	1.19	(1.05 – 1.35)	0.006	1.23	(1.10 – 1.37)	<0.001
-ChrIRD^#	1.38	(1.17 – 1.64)	<0.001	1.25	(1.06 – 1.46)	0.007
-Non-ChrIRD^#	1.11	(0.94 – 1.30)	0.21	1.20	(1.05 – 1.39)	0.010
Death	1.65	(1.36 – 2.00)	<0.001	1.28	(1.05 – 1.56)	0.014

Adjusted HRs use a time-dependent indicator for event type. Other baseline covariates in the model include: age, race, gender, BMI, log₁₀ CD4, log₁₀ nadir CD4, prior AIDS event, Hepatitis B or C co-infection, use of lipid-lowering medication, use of blood pressure medication, and type of ART treatment.

^{^}

All models were stratified by study (ESPRIT or SMART).

⁺

CVD by grade 4 but not by ERC, i.e. CVD by ERC and CVD by grade 4 are mutually exclusive for each subject

Some subjects have both a ChrIRD event and a non-ChrIRD event. These subjects would only be counted once for grade 4 events, so the ChrIRD and non-ChrIRD event counts do not sum to the grade 4 event count.

CVD = cardiovascular disease

ERC = endpoint review committee

ChrIRD = chronic inflammation-related disease