Table 1.

Toxicity and dose titration studies

Experiment	N	Skin Grafts Per Animal	Treatment	Treatment Frequency	Study End Point
1 (empty vehicle)	2	3 autologous STSGs	• Control (BacitracinTM) • TyroSpheres-gel (from POD 0) • TyroSpheres-gel (from POD 2)	Every other day up to POD 8	POD 14
2 (toxicity and systemic uptake)	2	1 autologous STSG	• 2.0 mL CSA-TyroSpheres-gel dressing (from POD 0)	Every other day	POD 14
3 (dose response)	1	4 autologous STSGs	• CSA-TyroSpheres-gel dressing (from POD 0) • 0.2 ml • 0.5 ml • 1.0 ml • Control (BacitracinTM)	Every other day	POD 14

CSA, cyclosporine-A; POD, postoperative day; STSG, split-thickness skin graft.