Table 1. Multiple myeloma cell line characterisitics (cytogenetic, IC50 melphalan and NER proficiency).
| Cell line | Cytogenetic | TP53 status | Melphalan IC50 (μm) | Melphalan+sp. IC50 (μm) | % of IC50 decrease |
|---|---|---|---|---|---|
| LR5 | t(14;16) | HD | 107.5 | 31.92 | 67.34 |
| LP1 | t(4;14) | HD | 91.03 | 79.12 | 18.93 |
| DOX40 | t(14;16) | HD | 63.74 | 20.99 | 60.52 |
| MR20 | t(14;16) | HD | 59.52 | 15.45 | 63.38 |
| KMS12BM | t(11;14) | HD | 56.07 | 13.78 | 75.79 |
| GM21148 | ERCC3 mutant | 53.66 | 56.99 | - | |
| U266 | t(11;14) | HD | 50.96 | 32.63 | 34.87 |
| KMS34 | t(4;14) | HD | 44.61 | 39.64 | 23.06 |
| KMS18 | t(4;14) | 42.91 | 9.23 | 78.93 | |
| RPMI8226 | t(14;16) | HD | 41.42 | 14.48 | 69.2 |
| MM1R | t(14;16) | WT | 41.08 | 16.88 | 43.48 |
| IM-9 | 34.96 | 23.95 | 30.52 | ||
| KMS12PE | t(11;14) | HD | 34.53 | 25.02 | 40.24 |
| JJN3 | t(14;16) | HD | 32.33 | 12.93 | 65.89 |
| OPM2 | t(4;14) | HD | 30.21 | 7.6 | 76.01 |
| MOLP8 | t(11;14) | 23.37 | 16.51 | 40.03 | |
| KMS11-TKO | t(4;14) MMSETII KO | HD | 22.56 | 8.76 | 61.17 |
| KMS26 | t(4;14) | HD | 21.95 | 5.81 | 72.05 |
| MM1S | t(14;16) | WT | 17.91 | 12.59 | 14.12 |
| KMS11 | t(4;14) | HD | 17.72 | 10.31 | 42.59 |
| NCIH929 | t(4;14) | WT | 12.39 | 10.31 | 30.65 |
Abbreviations: HD, homozygous deletion or homozygous mutation; IC50, half-maximal inhibitory concentration; NER, nucleotide excision repair; sp., spironolactone; WT, wild type.