Table 2. Frequency of driver mutations in p-SQCC compared to c-SQCC.
| Driver mutations | p-SQCC (n=145) | c-SQCC (n=268) | P |
|---|---|---|---|
| EGFR | 9 (6.2%) | 6 (2.2%) | 0.040 |
| KRAS | 5 (3.4%) | 4 (1.5%) | 0.288 |
| HER2 | 2 (1.4%) | 0 (0) | 0.123 |
| BRAF | 0 (0) | 1 (0.4%) | 1.000 |
| PIK3CA* | 7 (4.8%) | 6 (2.2%) | 0.150 |
| DDR2 | 0 (0) | 1 (0.4%) | 1.000 |
| AKT1 | 1 (0.7%) | 0 (0) | 0.351 |
| ALK | 0 (0) | 2 (0.7%) | 0.543 |
| FGFR | 4 (2.8%) | 9 (3.4%) | 1.000 |
| All | 26 (17.9%) | 29 (10.8%) | 0.042 |
*, one PIK3CA mutation was concurrent with EGFR mutation, one PIK3CA mutation was concurrent with KRAS mutation. p-SQCC, peripheral lung squamous cell carcinoma; c-SQCC, central lung squamous cell carcinoma.