Table 6.
Initial specific to non-specific binding ratios (SNBRs), absolute annual reduction (AAR), and relative annual reduction (RAR) of striatal subregions in the early stage of Parkinson’s disease (PD) and more advanced stage of PD groups
| Initial SNBR | AAR (/year) | RAR (%/year) | |||||
|---|---|---|---|---|---|---|---|
| Region | Side | Early | Advanced | Early | Advanced | Early | Advanced |
| Total striatum | Contralateral | 4.2 ± 1.2* | 3.2 ± 0.9 | 0.26 ± 0.13 | 0.24 ± 0.15 | 6.6 ± 3.3 | 7.8 ± 4.1 |
| Ipsilateral | 4.7 ± 1.4* | 3.6 ± 0.8 | 0.28 ± 0.14 | 0.25 ± 0.15 | 6.5 ± 3.2 | 7.0 ± 4.0 | |
| Mean | 4.4 ± 1.2* | 3.4 ± 0.8 | 0.27 ± 0.13 | 0.25 ± 0.15 | 6.6 ± 3.1 | 7.3 ± 4.0 | |
| Subregion | |||||||
| CA | Contralateral | 5.2 ± 1.6 | 4.2 ± 1.4 | 0.28 ± 0.20 | 0.31 ± 0.21 | 5.7 ± 3.8 | 7.9 ± 4.9 |
| Ipsilateral | 5.5 ± 1.6 | 4.6 ± 1.2 | 0.26 ± 0.20 | 0.27 ± 0.24 | 5.2 ± 3.8 | 5.8 ± 5.1 | |
| Mean | 5.4 ± 1.6 | 4.4 ± 1.3 | 0.27 ± 0.20 | 0.29 ± 0.22 | 5.4 ± 3.7 | 6.8 ± 4.9 | |
| VS | Contralateral | 5.0 ± 1.2 | 4.5 ± 1.0 | 0.20 ± 0.18 | 0.25 ± 0.21 | 4.2 ± 3.7 | 5.5 ± 4.1 |
| Ipsilateral | 5.3 ± 1.3 | 4.7 ± 0.7 | 0.19 ± 0.22 | 0.26 ± 0.18 | 3.8 ± 4.4 | 5.4 ± 3.7 | |
| Mean | 5.2 ± 1.3 | 4.6 ± 0.9 | 0.19 ± 0.19 | 0.26 ± 0.19 | 4.0 ± 4.0 | 5.4 ± 3.7 | |
| AP | Contralateral | 4.0 ± 1.3* | 3.1 ± 1.2 | 0.29 ± 0.14 | 0.26 ± 0.15 | 7.9 ± 4.2 | 9.1 ± 4.5 |
| Ipsilateral | 4.7 ± 1.6* | 3.7 ± 1.1 | 0.35 ± 0.19 | 0.30 ± 0.23 | 8.3 ± 4.8 | 8.2 ± 5.0 | |
| Mean | 4.4 ± 1.4* | 3.4 ± 1.1 | 0.32 ± 0.15 | 0.28 ± 0.18 | 8.1 ± 4.2 | 8.6 ± 4.6 | |
| PP | Contralateral | 2.7 ± 0.9* | 1.7 ± 0.7 | 0.25 ± 0.12* | 0.16 ± 0.12 | 9.4 ± 3.4 | 9.3 ± 5.2 |
| Ipsilateral | 3.4 ± 1.2* | 2.1 ± 0.7 | 0.30 ± 0.11* | 0.21 ± 0.11 | 9.5 ± 3.2 | 9.9 ± 4.2 | |
| Mean | 3.1 ± 1.0** | 1.9 ± 0.7 | 0.28 ± 0.10* | 0.18 ± 0.11 | 9.5 ± 3.0 | 9.7 ± 4.5 | |
*< 0.05, **< 0.001; CA caudate nucleus; VS ventral striatum; AP anterior putamen; PP posterior putamen