Figure 1.

Spatio-temporal differences in geometric, material and structural properties. Mean ± s.e.m. values of (a) distensibility MPa⁻¹, (b) unloaded wall thickness (μm), (c) axial stretch, (d,e) circumferential and axial stress (kPa), (f,g) circumferential and axial stiffness (MPa) and (h) stored energy (kPa) from four aortic regions (ATA, DTA, SAA, IAA; see electronic supplementary material, figure S2) at six times throughout AngII infusion: baseline (0 days), 4, 7, 14, 21 and 28 days (n = 4–7 samples per group). Significant differences from baseline (0 days) denoted by ⁺, *, **, *** p < 0.1, 0.05, 0.01, 0.001. Values for all metrics are in electronic supplementary material, table S2 and were computed at time-specific systolic pressures (electronic supplementary material, table S1), unless otherwise indicated. Note, in particular, the distinctive time course of changes in circumferential material stiffness in the ATA and circumferential stress in the SAA, with the most dramatic late thickening of the wall in the DTA and the modest changes overall in the IAA.