Figure 3.

Phenotypic plasticity. Simulations of a lattice-gas cellular automaton (LGCA) model taking into account the ‘Go-or-Grow’ mechanism, cell–cell repulsion and a cell density-dependent switch between a migrating and a proliferative phenotype. Simulation results (in blue) against experimental data (in red). (a) Temporal evolution of the core radius (dotted line) and invasive radius (solid line). (b) Temporal evolution of the ratio of core to invasive radius. (c) Velocity field diagram indicating the direction of glioma cell movement. (d) Visualization of the spatial tumour structure, where the grey level refers to the number of cells per node. Figure reproduced with permission from [25].