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| Secretion (hours from exposure) |
| Starts: immediate |
| Peaks: 2–4 |
| Factors that affect concentration levels |
| Increase |
| Inflammatory disease: rheumatoid arthritis, Crohns disease |
| Lymphoproliferative disease: Castleman’s disease |
| Malignancy: multiple myeloma, prostate carcinoma, ovarian carcinoma |
| Cardiac myxoma |
| Decrease |
| Late infection |
