Fig 1.

Somatic TP53 mutations in patients with adrenocortical tumors (ACTs) without TP53 mutations. (A) Schematic diagram of acquired TP53 mutations. (B) Kaplan-Meier estimates for progression-free survival (B) in pediatric patients with ACTs with or without acquired TP53 mutations and (C) by TP53 status and disease stage. After discriminating for disease stage and including stage IV disease in the Cox regression model, presence of somatic TP53 mutations was no longer associated with outcome (P = .21). hom, homozygous.