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. 2017 Oct 16;191(1):19–31. doi: 10.1111/cei.13046

Figure 2.

Figure 2

In‐vivo study of histone deacetylase (HDA)C6 inhibition reduces interferon (IFN)‐α production from plasmacytoid dendritic cells (pDCs). (a) Representative flow cytometry plots of subtypes of pDCs in bone marrow are shown. (b) The percentage of pDCs with low ability [major histocompatibility complex (MHC‐II)+ lymphocyte antigen 6 (Ly6a)+ pDCs] and high ability (MHC‐II– Ly6a– pDCs) of secreting IFN‐α. (c) IFN‐α production of sorted pDCs from bone marrow upon cytosine–phosphate–guanosine (CpG) stimulation for 12 h. *P < 0·05; **P < 0·01; ***P < 0·001; one‐way analysis of variance (anova), n ≥ 4. [Colour figure can be viewed at wileyonlinelibrary.com]