Figure 3.

Regulatory T cells (T_regs) from systemic lupus erythematosus (SLE) patients are deficient in K63 ubiquitinated substrates. Lys63 (K63) protein expression was assessed in CD4⁺CD25⁺ T_reg lysates from SLE patients and healthy controls by Western blotting. A representative image of a Western blot for K63 from an SLE patient versus healthy control is shown (a), as well as the pooled data from 30 SLE patients and 30 age‐ and sex‐matched healthy controls normalized K63 protein expression (b). Ctl = healthy controls; AU = arbitrary units.