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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Curr Biol. 2017 Aug 21;27(16):R816–R824. doi: 10.1016/j.cub.2017.06.012

Figure 2. Protein architecture of the human kinetochore.

Figure 2

A Cartoon of the organization of sister kinetochores on a human chromosome. The inter-centromeric localization of Aurora BIpl1 and MCAK is highlighted. B Top: Schematic displays a hypothetical spatial manifestation of the biochemical pathways of kinetochore assembly. Orange arrows indicate pathways of Ndc80 recruitment; grey dashed lines represent the microtubule. Note that CENP-TCnn1 recruits two Ndc80 molecules. Bottom: Cartoon of a hypothetical local architecture of the kinetochore-microtubule attachment in humans.