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. 2017 Oct 30;1(10):1043–1057. doi: 10.1002/hep4.1115

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© 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Alcohol‐induced oxidative stress is increased in hCYP2E1 compared to Wt mice. CYP2E1‐induced oxidative stress during alcohol consumption is a major pathology during alcoholic liver disease. (A) Representative images of immunohistochemistry staining of 4‐HNE are shown with quantification of the positive area. (B) Liver mRNA of ROS production genes was measured in Wt and hCYP2E1 mice after iG alcohol feeding. (C) Hepatic lipid peroxidation was assessed by measuring TBARS formation. The data are shown as the fold change of mRNA induction compared with Wt chow mice. The P value was measured between Wt and hCYP2E1 under iG alcohol feeding; the data were shown as mean ± SEM; *P < 0.05. Abbreviations: EtOH, ethanol; iG, intragastric; TBARS, thiobarbituric acid reactive substances.