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. 2017 Oct 30;1(10):1043–1057. doi: 10.1002/hep4.1115

Figure 5.

Figure 5

Transcriptional regulation of Accα by Nrf2. Acc is the speed‐limiting enzyme for de novo lipogenesis. Acc is regulated by AMPK at the posttranslational level and Nrf2 at the transcriptional level. (A) Western blotting of pAcc, Acc, pAMPK, and AMPK from the liver of Wt or hCYP2E1 mice. (B) Immunohistochemistry staining of Nrf2 on the liver sections of Wt and hCYP2E1 mice. The nuclear staining of Nrf2 is indicated by arrows. (C) mRNA level of Nrf2 and its transcriptional targets in the liver. The P value was measured between Wt and hCYP2E1 under iG alcohol feeding; the data were shown as mean ± SEM; *P < 0.05. Abbreviations: EtOH, ethanol; iG, intragastric; pAMPK, phosphorylated AMPK. Abbreviations: EtOH, ethanol; Gclc, glutamate‐cysteine ligase, catalytic subunit; Hmox1, heme oxygenase 1; Mt1, metallothionein 1; Nrf2, nuclear factor, erythroid derived 2, like 2; Nqo, NAD(P)H dehydrogenase, quinone 1.