Table 1.

MAJOR PARAMETERS

Parameter	Value	95% Interval	Distribution	Source
Treatment Management Costs	831.63	342–1029	Lognormal	1
Annual Medical Costs, Post Treatment
Year 1	224.88	123–370	Lognormal	1
Years 2–5	112.44	62–185	Lognormal	1
Years 6+	56.22	27–81	Lognormal	1
Genotype 1
Probability of SVR	0.972	0.964‐0.978	Beta	Appendix 6
Cost of treatment	$66,686	NA	NA	Appendix 7
Utility decrement	0	0	NA	Assumption
Genotype 2
Probability of SVR	0.993	0.98‐1.0	Beta	Appendix 6
Cost of treatment	$74,760	NA	NA	Appendix 7
Utility decrement	0	NA	NA	Assumption
Genotype 3:
Probability of SVR	0.848	0.927‐0.966	Beta	Appendix 6
Cost of treatment	$80,472	NA	NA	Appendix 7
Utility decrement	0	NA	NA	Assumption
Annual Stage Costs, Medicare Patients
Chronic infection or cirrhosis	$2,708	‐$918–$6,376	Lognormal	Medicare claims
Decompensated cirrhosis	$34,976	$27,616–$42,422	Lognormal	Medicare claims
HCC	$35,011	$25,760–$43,895	Lognormal	Medicare claims
Transplant, per year	$22,638	$11,319–$33,957	Lognormal	Medicare claims
Annual Stage Costs, Non‐Medicare Patients
Chronic infection*	$5,275	SE: $177	Normal	16
Cirrhosis	$6,746	SE:$672	Normal	16
Decompensated cirrhosis	$13,589	SE:$941	Normal	16
HCC	$35,940	SE:$10,505	Normal	16
Transplant	$102,530	SE: $30,406	Normal	16
Annual Stage QALYs
Chronic infection	0.86	NA	NA	17, 18, 20, 21, 22, 23
Cirrhosis	0.81	NA
Decompensated cirrhosis	0.7	NA
HCC	0.67	NA
Transplant	0.78	NA
Dead	0	NA

Annual stage costs for chronic infection assumed to be zero for uninsured patients.

Abbreviations: NA, not applicable; SE, standard error, in lieu of 95% confidence interval.