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. 2017 Mar 9;1(2):110–121. doi: 10.1002/hep4.1022

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© 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Replication of patient‐derived HBV molecular clones and susceptibility to ETV (A: Case A with VBT, B: Case B with VBT, C: Case C with partial virological response, D: Case D with flare‐up). HBV molecular clones were transfected into HepG2 cells, and ETV was administered to the transfected cells at the indicated concentrations. HBV replication and its reduction by ETV administration were assessed by measuring the intracellular core‐particle‐associated HBV DNA using Southern blotting (upper panel) and real‐time PCR (lower panel). The results are shown as the means ± SD. Abbreviations: DSL, double‐stranded liner HBV DNA; RC, relaxed circular HBV DNA; SS, single‐stranded HBV DNA.