Table 2.
A COMPARISON OF 333 PATIENTS WITH HEPATOCELLULAR CARCINOMA: SURVEILLANCE VERSUS NO SURVEILLANCE
| Surveillance | |||
|---|---|---|---|
| No | Yes | P value | |
| Number of patients | 158 | 175 | |
| Age (years)a | 59.8 ± 13.2 | 63.5 ± 11.1 | 0.0065 |
| Virology (number, %) | 0.049 | ||
| HBV | 90 (57) | 80 (45.7) | |
| HCV | 65 (41.1) | 94 (53.7) | |
| Both | 3 (1.9) | 1 (0.60) | |
| Albumin (g/dL)a | 3.6 ± 0.7 | 3.8 ± 0.7 | 0.27 |
| Total bilirubin (mg/dL)a | 1.9 ± 3.3 | 1.4 ± 2.2 | 0.25 |
| Alkaline phosphate (U/L)a | 183.3 ± 203.6 | 118.9 ± 61.3 | <0.0001 |
| AST (U/L)a | 123.7 ± 109.7 | 83 ± 104.7 | <0.0001 |
| ALT (U/L)a | 85.9 ± 62.4 | 67.6 ± 49.3 | 0.0065 |
| Platelets ( × 103 mm3)a | 187.6 ± 119.3 | 126.6 ± 70.5 | <0.0001 |
| AFP (ng/mL, %) | 0.0015 | ||
| Number < 10 | 150 | 174 | |
| Number > 10 | |||
| AFP in those > 10 (ng/mL) | 4,9279.9 ± 221,286.6 | 2,645.9 ± 11,480.7 | |
| Cirrhosis (number, %) | 0.24 | ||
| No | 37 (23.4) | 34 (19.4) | |
| Yes | 117 (74.1) | 140 (80.0) | |
| Missing | 4 (2.5) | 1 (0.60) | |
| Hepatitis B | <0.0001 | ||
| No treatment (number, %) | 69 (76.7) | 42 (52.5) | |
| Treatment (number, %) | 14 (15.6) | 38 (47.5) | |
| Unknown | 7 (7.8) | ‐ | |
| Hepatitis C | 0.01 | ||
| No treatment (number, %) | 56 (86.2) | 68 (72.3) | |
| Treatment (number, %) | 5 (7.7) | 22 (23.4) | |
| Unknown | 4 (6.2) | 4 (4.3) | |
| Child‐Pugh score (number, %) A | 0.0001 | ||
| B | 99 (62.7) | 145 (82.9) | |
| C | 50 (31.6) | 22 (12.6) | |
| Missing | 7 (4.4) | 8 (4.60) | |
| 2 (1.3) | 0 | ||
| Milan (number, %) | <0.0001 | ||
| Beyond | 113 (71.5) | 30 (17.1) | |
| Within | 45 (28.5) | 145 (82.9) | |
| UCSF (number, %) | <0.0001 | ||
| Beyond | 94 (59.5) | 16 (9.10) | |
| Within | 64 (40.5) | 159 (90.9) | |
| Diffuse (number, %) No | <0.0001 | ||
| Yes | 100 (63.3) | 167 (95.4) | |
| 58 (36.7) | 8 (4.60) | ||
| Macrovascular invasion (number, %) | <0.0001 | ||
| No | 103 (65.2) | 164 (93.7) | |
| Yes | 27 (17.1) | 6 (3.40) | |
| Missing | 28 (17.7) | 5 (2.90) | |
| Metastasis to lung (number, %) | |||
| No | 87 (55.0) | 142 (81.1) | |
| Yes | 18 (11.4) | 4 (2.30) | |
| Missing | 53 (33.5) | 29 (16.6) | <0.0001 |
| Metastasis to bone (number, %) | <0.0001 | ||
| No | 87 (55.1) | 143 (81.7) | |
| Yes | 18 (11.4) | 3 (1.7) | |
| Missing | 53 (33.5) | 29 (16.6) | |
| Median size of largest tumor (cm) | 5 | 3 | <0.001 |
| Number of tumors (number, %) | <0.0001 | ||
| 1 | 82 (51.9) | 132 (75.4) | |
| ≥2 | 76 (48.1) | 43 (24.6) | |
a
Mean ± SD
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus DNA; HCV, hepatitis C virus RNA.