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. 2017 Sep 26;1(9):871–885. doi: 10.1002/hep4.1102

Figure 2.

Figure 2

Pol II occupancy on four cell‐cycle regulatory genes indicates robust entry into and synchrony of the cell‐division cycle after PH. (A‐D) Pol II occupancy (a; pink) on transcription units of (A) Cdk2, (B) Ccnd1, (C) Ccna2, and (D) Ccnb1 revealed by ChIP‐Seq (Rib L, Villeneuve D, Praz V, Hernandez N, Guex N, Herr W, manuscript in preparation) and corresponding quantifications of (b) promoter‐bound Pol II (Pol II promoter) and (c) Pol II within the gene body (Pol II body), together with (d) their corresponding transcript levels revealed by RNA‐Seq (Rib L, Villeneuve D, Praz V, Hernandez N, Guex N, Herr W, manuscript in preparation) of the indicated PH (Post PH) and sham‐operated (Post sham) time points. The transcriptional start site is indicated by an arrow. Black bars in panel a equal 2 Kb. Abbreviation: RPKM, reads per kilobase million.