Fig. 2.

Required sets of experimental parameters for conversion of poorly soluble particle (PSP) exposure concentration into normalized delivered dose using particle-lung deposition and particokinetics models for in vivo inhalation (e.g. MPPD V3.04, [13]) and in vitro exposures under air-liquid interface [9] or submerged exposure conditions (ISDD model, [14, 19]). The list of required parameters (without repetitions) is given in bold letters for each of the three exposure scenarios. As caveat we add that toxicological measurements should be performed under stable particokinetic conditions, i.e. both mobility diameter and effective mobility density should be constant during the exposure time