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. Author manuscript; available in PMC: 2017 Dec 8.
Published in final edited form as: Biochemistry. 2017 Aug 31;56(36):4751–4756. doi: 10.1021/acs.biochem.7b00711

Figure 4.

Figure 4

Conformational changes in the AT at room temperature. The panels show conformational changes in the vicinity of Gln156. All residues are labeled in the room-temperature structure; the other structures are drawn in an analogous orientation. Panel A shows the interactions observed in the XFEL room-temperature structure. Panel B shows the interactions observed in the 100 K structures of the native enzyme and the acetate complex. Panel C shows the interactions observed in the 100 K structures of the malonate and citrate complexes. Panel D shows the surface representation highlighting the pathway. The 2Fo — Fc maps are contoured at 1.0σ