Table 7.

Values of V(prescription) for the planning target volume and differences in V(prescription) values relative to control for each of the 10 study patients, ^a using varying combinations of regions of interest to drive the deformations in the four‐dimensional (4D) dose calculations

Patient	Prescription dose (Gy)	V(prescription) values (%)						V(prescription) differences (%)
		LHCE	LHC	LH	LE	LC	L	LHC– LHCE	LH– LE– LHCE LHCE	LC– LHCE	L– LHCE
1	54.0 b	99.89	99.86	99.86	99.97	99.96	99.96	0.00	$-0.03$	$-0.03$	0.08	0.07
2	50.4	99.11	99.71	99.15	99.81	99.99	48.31	0.60	0.04 0.70	0.88	$-50.80$
3	45.0 c	99.00	98.99	96.14	99.11	94.04	65.67	$-0.01$	$-2.86$	0.11	$-4.96$	$-33.33$
4	70.0	100.00	100.00	99.67	99.84	89.33	74.35	0.00	$-0.33$	$-0.16$	$-10.67$	$-25.65$
5	63.0	99.36	97.13	69.93	67.83	41.75	0.00	$-2.23$	$-29.43$	$-31.53$	$-57.61$	$-99.36$
6	40.0 d	99.63	93.51	80.33	60.79	13.36	0.00	$-6.12$	$-19.30$	$-38.84$	$-86.27$	$-99.63$
7	63.0	97.86	96.54	91.53	96.26	88.77	54.13	$-1.32$	$-6.33$	$-1.60$	$-9.09$	$-43.73$
8	63.0	77.10	73.32	65.51	61.34	45.36	12.23	$-3.79$	$-11.60$	$-15.76$	$-31.74$	$-64.87$
9	60.0	79.32	77.91	74.69	75.76	51.85	41.31	$-1.41$	$-4.63$	$-3.57$	$-27.47$	$-38.02$
10	50.4	96.72	89.97	69.03	75.55	67.28	18.12	$-6.75$	$-27.69$	$-21.16$	$-29.43$	$-78.60$
RMS deviation								3.26	14.87	17.93	36.89	61.56
Maximum deviation								6.75	29.43	38.84	86.27	99.63

^aIn 3 cases in which the plan actually delivered a lower dose to the clinical target volume (CTV), the actual dose delivered to the CTV is identified as the prescription dose.

^bThe prescription dose of 60.0 Gy was to be delivered to the gross tumor volume. The prescription to the CTV was 54.0 Gy.

^cAlthough the prescription dose was 50.4 Gy, the plan actually delivered 45.0 Gy to the CTV.

^dAlthough the prescription dose was 50.0 Gy, the plan actually delivered 40.0 Gy to the CTV.

V(prescription) = fractional volume of planning target volume receiving at least prescription dose; $\mathrm{L}\mathrm{H}\mathrm{C}\mathrm{E}=4\mathrm{D}$ dose calculation driven by deformations of lung, heart, cord, external contour; $\text{LHC}=4\mathrm{D}$ dose calculation driven by deformations of lung, heart, cord; $\mathrm{L}\mathrm{H}=4\mathrm{D}$ dose calculation driven by deformations of lung, heart; $\mathrm{L}\mathrm{E}=4\mathrm{D}$ dose calculation driven by deformations of lung, external contour; $\mathrm{L}\mathrm{C}=4\mathrm{D}$ dose calculation driven by deformations of lung, cord; $\mathrm{L}=4\mathrm{D}$ dose calculation driven by deformations of lung; RMS = root mean square.