Table 3.
Multivariable Predictors of Clinical Events, Mortality, and Mortality Under Conservative Management
| Increment | MV Surgery or Deatha | All‐Cause Mortalityb | Mortality on Medical Treatmentb | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | ||
| LV end‐systolic diameter | 5‐mm increase | 1.08 (0.87–1.34) | 0.48 | 1.18 (0.91–1.52) | 0.21 | 1.13 (0.81–1.58) | 0.46 |
| Forward LVEF | 5% decrease | 1.09 (1.02–1.17) | 0.01 | 1.14 (1.05–1.24) | 0.0007 | 1.13 (1.04–1.24) | 0.005 |
| Indexed LA diameter | 1‐mm/m2 increase | 1.06 (1.02–1.10) | 0.004 | 1.05 (0.99–1.11) | 0.11 | 1.04 (0.97–1.11) | 0.28 |
| Trans‐tricuspid gradient | 5‐mm Hg increase | 1.01 (0.90–1.13) | 0.86 | 0.99 (0.86–1.14) | 0.87 | 0.97 (0.82–1.15) | 0.76 |
ACE indicates angiotensin‐converting enzyme inhibitors; CI, confidence interval; LA, left atrial; LV, left ventricular; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; MV, mitral valve.
a
Adjusted for: age, sex, MR severity, Charlson probability, coronary artery disease, atrial fibrillation, and ACE inhibitors.
b
Adjusted for: age, sex, MR severity, Charlson probability, and mitral valve surgery.