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. 2017 Nov 14;6(11):e006441. doi: 10.1161/JAHA.117.006441

Figure 1.

Figure 1

Cumulative concentration‐response curves of aortic rings isolated 8 days after Roux‐en‐Y gastric bypass (RYGB) or sham surgery/start of treatment after submaximal contraction to norepinephrine in response to glucagon‐like peptide‐1 (GLP‐1; A) and insulin (B) in RYGB rats, controlD‐TAT rats, and rats treated with the peptide inhibitor D‐JNKi‐1 (D‐JNK rats) (n=7–13 per group). Ex vivo relaxation of aortic rings with or without 30 minutes ex vivo preincubation with 5 μmol/L D‐JNK. Concentration‐response curves after submaximal contraction to norepinephrine in response to GLP‐1 (C) and insulin (D) in controlD‐ TAT rats and to GLP‐1 (E) and insulin (F) in D‐JNK rats (n=3–6 per group). Results are evaluated by 2‐way repeated measures ANOVA and Bonferroni post hoc test. Data are shown as mean±SD. *P<0.05, ***P<0.001 for RYGB vs controlD‐ TAT; °°°P<0.001 for controlD‐ TAT vs D‐JNK; ## P<0.01, ### P<0.001 for controlD‐ TAT vs D‐TAT preincubated 30 minutes ex vivo with 5 μmol/L D‐JNK.