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. 2017 Nov 14;6(11):e006441. doi: 10.1161/JAHA.117.006441

Figure 2.

Figure 2

(A), c‐Jun N‐terminal kinase (JNK) 1 and JNK2 phosphorylation (46 and 55 kDa, respectively) in the aortas of lean chow‐fed D‐TAT vs obese controlD‐ TAT rats (determined by unpaired t test). Phosphorylation of aortic JNK1 and JNK2 (B), insulin receptor substrate‐1 (IRS‐1) Ser307 (C), and protein kinase B (Akt) Ser473 (D) in controlD‐ TAT, Roux‐en‐Y gastric bypass (RYGB), and peptide inhibitor D‐JNKi‐1 (D‐JNK) rats 8 days after surgery/start of treatment. Representative Western blots and densitometric quantifications are shown (determined by 1‐way ANOVA and Bonferroni post hoc test; n=4–13 per group). Results are shown as mean±SD. p indicates phosphorylated. ¢ P<0.05 for chow‐fed control peptide D‐TAT vs controlD‐ TAT, *P<0.05 for RYGB vs controlD‐ TAT, °P<0.05 for controlD‐ TAT vs D‐JNK.