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. 2017 Nov 14;6(11):e006441. doi: 10.1161/JAHA.117.006441

Figure 4.

Figure 4

(A), Reduced nicotinamide ADP (NADPH) oxidase activity in aortas (determined by 1‐way ANOVA and Bonferroni post hoc test; n=6–13 per group). (B), Fasting plasma glucagon‐like peptide‐1 (GLP‐1) levels in controlD‐ TAT, Roux‐en‐Y gastric bypass (RYGB), and peptide inhibitor D‐JNKi‐1 (D‐JNK) rats 8 days after surgery/start of treatment (determined by Kruskal‐Wallis test and Dunn multiple comparison test; n=6–13 per group). Aortic GLP‐1 receptor expression (C) and phosphorylation of protein kinase A (p‐PKA) C‐α Thr197 (D) and cAMP response element binding protein (p‐CREB) Ser133 (E) in the same groups. Representative Western blots and densitometric quantifications are shown (determined by 1‐way ANOVA and Bonferroni post hoc test; n=6–13 per group). Results are shown as mean±SD (A and C‐E) or median±interquartile range (B). *P<0.05, **P<0.01 for RYGB vs all other groups; °P<0.05 for controlD‐TAT vs D‐JNK.