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. 2017 Nov 8;6(11):e006513. doi: 10.1161/JAHA.117.006513

Table 10.

Multivariable Linear Regression for Assessing Association Between Change in Circulating Cardiovascular Biomarkers and Change in the Ratio of Peak Early (E) Transmitral Velocity by Pulsed Doppler and Peak Early Tissue Doppler (E′) (E/E′) by Echocardiography With Adjustment for Variables That Could Affect Change in E/E′

Variables Ba 95% Confidence Interval for B P Value Variables Ba 95% Confidence Interval for B P Value
ΔcTnI −0.02 −0.05, 0.02 0.297 ΔcTnT −0.04 −0.09, 0.01 0.097
Age, y −0.02 −0.06, 0.01 0.197 Age, y −0.02 −0.06, 0.02 0.269
BMI, kg/m2 −0.03 −0.09, 0.04 0.451 BMI, kg/m2 −0.02 −0.09, 0.04 0.495
SBP, mm Hg 0.02 −0.01, 0.05 0.128 SBP, mm Hg 0.02 −0.01, 0.05 0.117
Epi. doseb 0.65 −0.08, 1.37 0.078 Epi. doseb 0.78 0.03, 1.52 0.041
Candesartan −0.25 −0.86, 0.35 0.408 Candesartan −0.24 −0.84, 0.36 0.423
Metoprolol 0.57 −0.04, 1.18 0.065 Metoprolol 0.55 −0.05, 1.16 0.072
ΔBNP 0.00 −0.02, 0.01 0.664 ΔNT‐proBNP 0.00 −0.01, 0.00 0.286
Age, y −0.02 −0.06, 0.02 0.259 Age, y −0.02 −0.06, 0.01 0.223
BMI, kg/m2 −0.03 −0.10, 0.03 0.328 BMI, kg/m2 −0.03 −0.10, 0.03 0.296
SBP, mm Hg 0.02 −0.01, 0.05 0.124 SBP, mm Hg 0.02 0.00, 0.05 0.102
Epi. doseb 0.64 −0.09, 1.38 0.085 Epi. doseb 0.65 −0.08, 1.37 0.078
Candesartan −0.28 −0.89, 0.33 0.369 Candesartan −0.24 −0.84, 0.37 0.437
Metoprolol 0.73 0.09, 1.37 0.025 Metoprolol 0.74 0.11, 1.37 0.023
ΔGalectin‐3 −0.03 −0.16, 0.10 0.673 ΔCRP 0.00 −0.02, 0.03 0.698
Age, y −0.02 −0.06, 0.02 0.240 Age, y −0.03 −0.06, 0.01 0.187
BMI, kg/m2 −0.03 −0.10, 0.03 0.330 BMI, kg/m2 −0.03 −0.09, 0.04 0.392
SBP, mm Hg 0.02 −0.01, 0.05 0.144 SBP, mm Hg 0.02 −0.01, 0.05 0.148
Epi. doseb 0.60 −0.13, 1.33 0.108 Epi. doseb 0.57 −0.17, 1.30 0.129
Candesartan −0.27 −0.89, 0.34 0.384 Candesartan −0.23 −0.84, 0.37 0.451
Metoprolol 0.69 0.06, 1.31 0.031 Metoprolol 0.62 0.02, 1.23 0.044

BMI indicates body mass index; BNP, B‐type natriuretic peptides; CRP, C‐reactive protein; cTnI, cardiac troponin I; cTnT, cardiac troponin T; NT‐proBNP, amino‐terminal fragment of the BNP prohormone; SBP, systolic blood pressure at baseline.

a

B unstandardized regression coefficient.

b

Dichotomized variable for cumulative epirubicin dose of 400 and <400 mg/m2.