Table 2.
Incidence and Risk of Composite Cardiovascular Events in Topical and Oral Nonselective NSAID Users
| Type of NSAID Use | Follow‐Up, Person‐Years | No. of Events | Crude Incidence per 100 Person‐Years | IPTW Weighted Cox Modela, b | Multivariate Cox Modela, c |
|---|---|---|---|---|---|
| Topical (N=10 758) | 1854.6 | 34 | 1.83 | 0.64 (0.43–0.95) | 0.54 (0.37–0.77) |
| Oral (N=78 056) | 20 205.3 | 433 | 2.14 | REF | REF |
IPTW indicates inverse probability of treatment weight; and REF, reference.
a
Data are given as hazard ratio (95% confidence interval).
b
IPTW was derived on the basis of the propensity score, which was calculated from the multivariable logistic regression model, conditional on all variables in Table 1.
c
Adjusted for all covariates listed in the Methods.