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. 2017 Nov 18;6(11):e006901. doi: 10.1161/JAHA.117.006901

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Efficacy outcomes by sex. Women had a significant 22% reduction of myocardial infarction and a 12% reduction of major adverse cardiac events (composite of cardiovascular death, myocardial infarction, and stroke) with ezetimibe compared with placebo. There were no significant treatment interactions by sex for any of the end points. CHD indicates coronary heart disease; CI, confidence interval; Eze, ezetimibe; HR, hazard ratio; KM, Kaplan‐Meier; PBO, placebo; P _int, P value for interaction; Simva, simvastatin.