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. 2017 Oct 28;6(11):e007030. doi: 10.1161/JAHA.117.007030

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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MYL4 del mutation rats do not show atrial cardiomyopathy. A through C, ECG data for WT (N=4), heterozygous, and homozygous MYL4 deletion mutation rats at different ages. Neither the MYL4 ^del+/− (N=5) nor MYL4 ^del+/+ (N=4) rats had significant arrhythmia. D through F, Echocardiography showed the absence of structural remodeling in MYL4 ^del+/− and MYL4 ^del+/+ rats. WT Rats: N=3; MYL4 ^del+/− rats: N=5; MYL4 ^del+/+ rats: N=3. G and H, Neither the MYL4 ^del+/− nor MYL4 ^del+/+ rats had significant atrial fibrosis (4–5 hearts per group, 6–10 fields per heart for each group). ECG indicates standard 12‐lead electrocardiography; MYL4, myosin light‐chain 4; N, number; WT, wild type.