Figure 3.

Bar graphs depict the concentration‐dependent effects of SDF‐1α (stromal cell‐derived factor 1α; 1, 3, and 10 nmol/L) on cell number (A and B), ³H‐leucine incorporation (C and D), and ³H‐proline incorporation (E and F) in cardiac fibroblasts (CFs) from spontaneously hypertensive rats (SHR; A, C, and E) and normotensive Wistar–Kyoto rats (WKY; B, D, and F) in the absence and the presence of sitagliptin (1 μmol/L). Each P value at the top of each main panel is the 3‐way interaction P value from a 3‐factor ANOVA. These P values demonstrate that the strain from which the cells were derived (SHR vs WKY) interacts with sitagliptin to determine the overall effects of SDF‐1α on cell number, ³H‐leucine incorporation, and ³H‐proline incorporation. Each P value at the top of each subpanel is the 2‐way interaction P value from a 2‐factor ANOVA. These P values demonstrate that for all 3 variables and for both SHR and WKY CFs, sitagliptin augmented responses to SDF‐1α. *Significant difference (P<0.05; Fisher least significant difference test) between the indicated concentration of SDF‐1α and the basal values (ie, values in the absence of SDF‐1α) for the indicated variable. ^†Significant difference (P<0.05; Fisher least significant difference test) between sitagliptin‐treated and non–sitagliptin‐treated cells at the indicated concentration of SDF‐1α. Values are means and SEM.