Table 4.
Multivariable Cox Analyses to Assess the Predictive Value of the Combination of On‐Treatment CP and SL for the LIFE Study Composite End Point in Relevant Subgroups of the Study Population
| Subgroup | Composite End Point, No. | HR | 95% CI | P Value for Interaction |
|---|---|---|---|---|
| Sex | 0.190 | |||
| Female (n=4963) | 476 | |||
| CP+/SL− | 1.44 | 1.12–1.84 | ||
| CP−/SL+ | 1.62 | 1.02–2.57 | ||
| CP+/SL+ | 3.02 | 2.18–4.18 | ||
| Male (n=4230) | 620 | |||
| CP+/SL− | 1.44 | 1.17–1.78 | ||
| CP−/SL+ | 1.99 | 1.49–2.66 | ||
| CP+/SL+ | 3.13 | 2.41–4.06 | ||
| Race | 0.154 | |||
| White/other (n=8660) | 1021 | |||
| CP+/SL− | 1.44 | 1.22–1.70 | ||
| CP−/SL+ | 1.82 | 1.40–2.37 | ||
| CP+/SL+ | 3.20 | 2.60–3.95 | ||
| Black (n=533) | 75 | |||
| CP+/SL− | 1.69 | 0.84–3.40 | ||
| CP−/SL+ | 1.80 | 0.81–3.95 | ||
| CP+/SL+ | 1.87 | 0.79–4.42 | ||
| Age | 0.481 | |||
| <65 y (n=3489) | 250 | |||
| CP+/SL− | 1.52 | 1.11–2.08 | ||
| CP−/SL+ | 1.90 | 1.15–3.14 | ||
| CP+/SL+ | 4.60 | 3.08–6.88 | ||
| ≥65 y (n=5704) | 846 | |||
| CP+/SL− | 1.52 | 1.26–1.82 | ||
| CP−/SL+ | 2.03 | 1.53–2.69 | ||
| CP+/SL+ | 2.98 | 2.36–3.77 | ||
| History of ischemic heart disease | 0.969 | |||
| No (n=7724) | 802 | |||
| CP+/SL− | 1.46 | 1.22–1.75 | ||
| CP−/SL+ | 1.76 | 1.32–2.35 | ||
| CP+/SL+ | 3.06 | 2.42–3.87 | ||
| Yes (n=1469) | 294 | |||
| CP+/SL− | 1.48 | 1.04–2.10 | ||
| CP−/SL+ | 2.45 | 1.52–3.96 | ||
| CP+/SL+ | 3.50 | 2.32–5.27 | ||
| Diabetes mellitus | 0.140 | |||
| No (n=7998) | 854 | |||
| CP+/SL− | 1.45 | 1.21–1.73 | ||
| CP−/SL+ | 1.64 | 1.24–2.17 | ||
| CP+/SL+ | 3.02 | 2.40–3.79 | ||
| Yes (n=1195) | 242 | |||
| CP+/SL− | 1.53 | 1.05–2.21 | ||
| CP−/SL+ | 3.40 | 2.03–5.68 | ||
| CP+/SL+ | 3.44 | 2.17–5.45 | ||
| Randomized treatment | 0.209 | |||
| Atenolol (n=4558) | 588 | |||
| CP+/SL− | 1.36 | 1.09–1.70 | ||
| CP−/SL+ | 1.45 | 1.01–2.07 | ||
| CP+/SL+ | 2.62 | 1.98–3.47 | ||
| Losartan (n=4605) | ||||
| CP+/SL− | 508 | 1.55 | 1.23–1.96 | |
| CP−/SL+ | 2.44 | 1.74–3.41 | ||
| CP+/SL+ | 3.78 | 2.82–5.08 |
CI indicates confidence interval; CP, Cornell product; HR, hazard ratio; LIFE, Losartan Intervention For Endpoint Reduction; SL, Sokolow‐Lyon voltage.